Protein Details: Chloride channel protein ClC-Kb

Protein ID

ICDB_Pro_0592

Protein Name

Chloride channel protein ClC-Kb

Gene Name

CLCNKB

Organism

Homo sapiens (Human)

Length

687 amino acids

AlphaFoldDB

AF-P51801-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Sequence

MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 121; /ligand="chloride" ; BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)"; BINDING 426; /ligand="chloride"

Disease

Bartter Syndrome;Type 3 and Bartter Syndrome;Type 4B;Neonatal;With Sensorineural Deafness

Location

Expressed predominantly in the kidney

DOI ID

10.1073/pnas.91.15.6943; 10.1038/ki.1995.439; 10.1038/ng1285; 10.1038/nature04727; 10.1038/35107099; 10.1056/nejmoa032843; 10.1136/jmg.2007.052944; 10.1038/ng1097-171

RefSeq

NP_000076.2 [P51801-1]; NP_001159417.2 [P51801-2]